Normative Aging Results in Degradation of Gene Networks in a Zebra Finch Basal Ganglia Nucleus Dedicated to Vocal Behavior
Voice and speech patterns change with normative aging and due to neurodegenerative diseases. The role of the brain in driving these vocal changes is not well understood prompting our current study. Here, we relate changes in aging birdsong across young adult, middle age, and old male zebra finches to mRNA level changes in thousands of interacting genes within a finch song-dedicated basal ganglia brain nucleus. Results will provide insight into pivotal molecular pathways driving age-related changes in vocal dysfunction that can be therapeutically targeted.
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